Ecology and Evolution of Antibiotic Resistance
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Institut Pasteur, CNRS UMR3525
28, Rue du Dr Roux
75015 Paris
France
Scientific Interest
Horizontal transfers play a major role in the spread of antibiotic resistance through the transmission of mobile genetic elements (MGEs) carrying resistance genes, but also through recombinational allelic exchanges, often also involving MGEs for DNA transfers by conjugation or transduction. In addition, insertion sequences (IS) and group 2 introns contribute to the rapid evolution of a strain by recombination and some ISs, such as IS26, contribute to the dissemination and amplification of resistance genes. Our research projects focus on understanding the emergence and dissemination of multidrug-resistant (MDR) Enterobacterales (E. coli and K. pneumoniae). In this context, we characterize the mobility of genetic elements in natural isolates (the real life) and analyze their evolutionary and ecological contribution to the dissemination of antibiotic resistance and to the evolution of MDR clones.
Horizontal transfers play a major role in the spread of antibiotic resistance through the transmission of mobile genetic elements (MGEs) carrying resistance genes, but also through recombinational allelic exchanges, often also involving MGEs for DNA transfers by conjugation or transduction. In addition, insertion sequences (IS) and group 2 introns contribute to the rapid evolution of a strain by recombination and some ISs, such as IS26, contribute to the dissemination and amplification of resistance genes. Our research projects focus on understanding the emergence and dissemination of multidrug-resistant (MDR) Enterobacterales (E. coli and K. pneumoniae). In this context, we characterize the mobility of genetic elements in natural isolates (the real life) and analyze their evolutionary and ecological contribution to the dissemination of antibiotic resistance and to the evolution of MDR clones.
Thematic