Mobility of pathogenic genomes and chromatin dynamics Retrotransposons and Genome Plasticity
cs_picture_multi_link
Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), CNRS UMR 5234, Université de Bordeaux
MFP lab,
Université de Bordeaux
147 Rue Léo Saignat
33076
Bordeaux
France
Scientific Interest
DNA and chromatin, or pseudochromatin, structures regulate numerous biological and pathogenic mechanisms as bacterial integrons mobilisation or retroviral integration. These processes constitute therapeutic target and attractive tools for gene transfer/therapy. Our team aims to understand these mechanisms in different models of mobile elements (viral infections, procaryotic, eukaryotic and viral integration/transposition) using complementary biophysics, biochemistry, structural/cellular biology and pharmacology approaches.
DNA and chromatin, or pseudochromatin, structures regulate numerous biological and pathogenic mechanisms as bacterial integrons mobilisation or retroviral integration. These processes constitute therapeutic target and attractive tools for gene transfer/therapy. Our team aims to understand these mechanisms in different models of mobile elements (viral infections, procaryotic, eukaryotic and viral integration/transposition) using complementary biophysics, biochemistry, structural/cellular biology and pharmacology approaches.
Thematic