Epigenetics, Reproduction and Transposable Elements
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GRANDBASTIEN Marie-Angèle
marie-angele.grandbastien@inrae.fr["GRANDBASTIEN Marie-Angèle","BORGES Filipe"]["marie-angele.grandbastien@inrae.fr","filipe.borges@inrae.fr"]
marie-angele.grandbastien@inrae.fr["GRANDBASTIEN Marie-Angèle","BORGES Filipe"]["marie-angele.grandbastien@inrae.fr","filipe.borges@inrae.fr"]
Institut Jean-Pierre Bourgin (IJPB), INRAE-AgroParisTech, UMR 1318, Université Paris Saclay
Bâtiment 2
INRAE Centre de Versailles-Grignon
Route de St-Cyr (RD10)
78026 Versailles Cedex (France)
Scientific Interest
The RETROS team studies plant transposable elements (TEs), notably LTR retrotransposons. Our model species are allotetraploid Nicotianae derived from hybridization between diploid species and genome doubling, and principally tobacco. We analyze retrotransposon response to external stresses et interspecific crosses, and their impact on genome evolution in a changing environment. We recently demonstrated that allopolyploidy-associated TE activation is correlated to parental TE divergence levels, thus confirming B. McClintock hypothesis that TE activation by genome shock is correlated to the confrontation of the divergent parental genomes. We are currently developing projects to evaluate the functional impact of LTR-RTs on the expression of tobacco genes. We have demonstrated that LTRs of several elements can initiate, in stress conditions, chimeric cotranscripts extending into adjacent sequences. By modulating adjacent gene expression, LTR-RTs could thus play a role in the host response to various stimuli. We have developed a collaboration with URGI (Unité de Recherche Génomique Info) to implement the REPET pipeline for de novo characterization of the TE component of tobacco and its diploid parental species. Our major objective is to evaluate whether chimeric LTR-RT transcript production could be involved in differential changes in the expression of orthologous genes transmitted by each parent. Such changes are indeed frequently observed in allopolyploids in response to environmental modifications, and may facilitate adaptation of the new hybrid species. Under external challenges, LTR-RTs may thus diversify the global stress response of hybrids and be involved in their evolutionary success.
The RETROS team studies plant transposable elements (TEs), notably LTR retrotransposons. Our model species are allotetraploid Nicotianae derived from hybridization between diploid species and genome doubling, and principally tobacco. We analyze retrotransposon response to external stresses et interspecific crosses, and their impact on genome evolution in a changing environment. We recently demonstrated that allopolyploidy-associated TE activation is correlated to parental TE divergence levels, thus confirming B. McClintock hypothesis that TE activation by genome shock is correlated to the confrontation of the divergent parental genomes. We are currently developing projects to evaluate the functional impact of LTR-RTs on the expression of tobacco genes. We have demonstrated that LTRs of several elements can initiate, in stress conditions, chimeric cotranscripts extending into adjacent sequences. By modulating adjacent gene expression, LTR-RTs could thus play a role in the host response to various stimuli. We have developed a collaboration with URGI (Unité de Recherche Génomique Info) to implement the REPET pipeline for de novo characterization of the TE component of tobacco and its diploid parental species. Our major objective is to evaluate whether chimeric LTR-RT transcript production could be involved in differential changes in the expression of orthologous genes transmitted by each parent. Such changes are indeed frequently observed in allopolyploids in response to environmental modifications, and may facilitate adaptation of the new hybrid species. Under external challenges, LTR-RTs may thus diversify the global stress response of hybrids and be involved in their evolutionary success.
