Genome dynamics and epigenetic variation (GDEV)
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Institut de Biologie de l’Ecole normale supérieure (Paris), CNRS UMR 8197, Inserm U1024
IBENS
46 rue d’Ulm
75230 Paris Cedex 05
France
Scientific Interest
Our group studies the contribution of transposable elements (TEs) to the creation of heritable phenotypic variation, adaptation and evolution. We are particularly interested in establishing the impact of chromatin-based epigenetic processes, notably DNA methylation, on all aspects of TE biology as well as on genome function. We use the flowering plant Arabidopsis thaliana as our main experimental model and implement advanced molecular genetics as well as genomic and epigenomic approaches to determine the distribution of TEs within and between genomes, the genetic and environmental factors that control TE methylation and mobilization, and the effect of TE insertions on their genic neighborhood.
Our group studies the contribution of transposable elements (TEs) to the creation of heritable phenotypic variation, adaptation and evolution. We are particularly interested in establishing the impact of chromatin-based epigenetic processes, notably DNA methylation, on all aspects of TE biology as well as on genome function. We use the flowering plant Arabidopsis thaliana as our main experimental model and implement advanced molecular genetics as well as genomic and epigenomic approaches to determine the distribution of TEs within and between genomes, the genetic and environmental factors that control TE methylation and mobilization, and the effect of TE insertions on their genic neighborhood.
Bioinfo Tools
[{"name":"TE-Sequence Capture: Massively parallel experimental detection of TE mobilization events in the model plant Arabidopsis thaliana. ","url":"https://doi.org/10.1007/978-1-0716-1134-0_14"},{"name":"SPLITREADER: bioinformatic pipeline for the detection of non-reference TE sequences in re-sequenced genomes.","url":"https://doi.org/10.1007/978-1-0716-1134-0_15"}]
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| Material Design Iconic Font | Codepen |