ICE : Transfer & Adaptation (ICE-TeA)
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Dynamique des Génomes et Adaptation Microbienne (DynAMic), UMR1128, Université de Lorraine
Faculté des Sciences et Technologies
Bd des Aiguillettes BP70239
54506 Vandœuvre-lès-Nancy
Scientific Interest
Our team studies bacterial mobile genetic elements that are chromosomal but able to excise as circular form and transfer by conjugation to other bacteria. These elements called Integrative Conjugative Elements (ICEs) or Conjugative Transposons participate in horizontal gene transfer (antimicrobial resistance, virulence, stress response…) and in the evolution of the genome in bacteria by several mechanisms: (i) by their autonomous transfer by conjugation, (ii) by mobilization in cis of genetic elements bordered by functional recombination sites, (iii) by mobilization in trans of excisable but non-autonomous elements for their transfer by conjugation (Mobilizable Integrative Elements or IMEs) and (iv) by Hfr-type transfer of long chromosomal fragments. Our studies focus on Firmicutes and combine experimental approaches (conjugation and gene mobilization experiments, biochemical characterization of the actors of the conjugation machinery…) and bioinformatics (genome annotation, for detection of elements in the genomes called ICE/IME-screen).
Our team studies bacterial mobile genetic elements that are chromosomal but able to excise as circular form and transfer by conjugation to other bacteria. These elements called Integrative Conjugative Elements (ICEs) or Conjugative Transposons participate in horizontal gene transfer (antimicrobial resistance, virulence, stress response…) and in the evolution of the genome in bacteria by several mechanisms: (i) by their autonomous transfer by conjugation, (ii) by mobilization in cis of genetic elements bordered by functional recombination sites, (iii) by mobilization in trans of excisable but non-autonomous elements for their transfer by conjugation (Mobilizable Integrative Elements or IMEs) and (iv) by Hfr-type transfer of long chromosomal fragments. Our studies focus on Firmicutes and combine experimental approaches (conjugation and gene mobilization experiments, biochemical characterization of the actors of the conjugation machinery…) and bioinformatics (genome annotation, for detection of elements in the genomes called ICE/IME-screen).
Bioinfo Tools
[{"name":"ICEscreen is a bioinformatic pipeline for the detection and annotation of ICEs (Integrative and Conjugative Elements) and IMEs (Integrative and Mobilizable Elements) in Bacillota genomes.","url":"https://forgemia.inra.fr/ices_imes_analysis/icescreen"}]
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