Intraspecific variation and genome evolution
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Génétique Moléculaire, Génomique, Microbiologie (GMGM), UMR7156, Université de Strasbourg
GMGM UMR7156
Plateforme de Biologie
4, allée K. Roentgen
67000 Strasbourg
Scientific Interest
Natural populations present an astonishing diversity of phenotypic variation in terms of morphology, physiology, behavior and disease susceptibility. One major goal in biology is to identify the genetic causes of trait variation. To obtain a better insight into the genotype-phenotype relationship, our team aims to exhaustively identify and describe genetic variants corresponding to the heritable phenotypic variation upon which selection can act. Because of their small and compact genomes, yeast species the Saccharomycotina subphylum (budding yeasts) represent an ideal system in which to obtain a complete picture of the intraspecific genetic polymorphisms at the levels of single nucleotide variants, copy number variations, small insertions and deletions (indels) and structural variations (SVs) including transposable elements (TEs). In this broad context, my research is dedicated to characterize the variation in TE contents and TE activity, in order to identify the mechanisms shaping these differences at the species wide level.
Natural populations present an astonishing diversity of phenotypic variation in terms of morphology, physiology, behavior and disease susceptibility. One major goal in biology is to identify the genetic causes of trait variation. To obtain a better insight into the genotype-phenotype relationship, our team aims to exhaustively identify and describe genetic variants corresponding to the heritable phenotypic variation upon which selection can act. Because of their small and compact genomes, yeast species the Saccharomycotina subphylum (budding yeasts) represent an ideal system in which to obtain a complete picture of the intraspecific genetic polymorphisms at the levels of single nucleotide variants, copy number variations, small insertions and deletions (indels) and structural variations (SVs) including transposable elements (TEs). In this broad context, my research is dedicated to characterize the variation in TE contents and TE activity, in order to identify the mechanisms shaping these differences at the species wide level.
Thematic