Silent – Silencing & Transposons
cs_picture_multi_link
Institut Génétique Reproduction et Développement (iGReD), CNRS UMR 6293, Inserm U1103, Université Clermont Auvergne
UFR de Médecine
28 place Henri Dunant
TSA 50400
63001 Clermont-Ferrand Cedex France
Scientific Interest
Gene silencing refers to various mechanisms of gene repression, which are epigenetic by nature and do not involve changes in the sequence of the DNA molecule. In both plants and animals, silencing is tightly associated with several epigenetic modifications of the chromatin such as cytosine DNA methylation and specific modification of histone proteins. Gene silencing does not only target exogenous DNA entering the genome, but also endogenous genomic sequences such as certain protein-coding genes and most transposable elements. Efficient and accurate gene silencing is therefore essential for proper gene expression and genome stability. We combine genetic and genomic approaches to understand the mechanisms of gene silencing.
Gene silencing refers to various mechanisms of gene repression, which are epigenetic by nature and do not involve changes in the sequence of the DNA molecule. In both plants and animals, silencing is tightly associated with several epigenetic modifications of the chromatin such as cytosine DNA methylation and specific modification of histone proteins. Gene silencing does not only target exogenous DNA entering the genome, but also endogenous genomic sequences such as certain protein-coding genes and most transposable elements. Efficient and accurate gene silencing is therefore essential for proper gene expression and genome stability. We combine genetic and genomic approaches to understand the mechanisms of gene silencing.
Thematic